CAN HYPOFRACTIONATED REIRRADIATION PLUS TEMOZOLAMIDE BE A WISE CHOICE FOR RECURRENT HIGH AND LOW GRADE BRAIN TUMORS?
نویسندگان
چکیده
منابع مشابه
Temozolomide and Reirradiation in Recurrent Grade II Brain Glioma
Background This phase II trial was designed to assess the response rate, survival benefits and toxicity profile of temozolomide, and brain reirradiation using conformal radiotherapy (CRT) for recurrent grade II brain glioma. Between February 2006 and June 2009, 18 patients with recurrent low grade glioma, and two with recurrent ependymoma were enrolled in the study. Patients had to show unequiv...
متن کاملDetermination of CD117 Expression in Glial Tumors and Its Comparison between High Grade and Low Grade Tumors
Background and Objective: Gliomas are the most common primary brain tumors. Despite therapeutic advances, the majority of gliomas do not respond to either chemo or radiotherapy. CD117, the gene product of c-kit has been expressed in cells of glial tumors. Because gastrointestinal stromal tumors (GISTs) that express CD117 respond dramatically to treatment with tyrosine kinase inhibitors, ide...
متن کاملA thought-provoking retrospective study on survival and toxicity after reirradiation for recurrent high-grade gliomas.
TO THE EDITOR: Fogh et al recently published a large singleinstitution study on hypofractionated stereotactic reirradiation for recurrent high-grade gliomas in which 147 patients were included, the vast majority (71%) with glioblastoma. The median initial radiotherapy dose was 60 Gy, and the median reirradiation dose was 35 Gy in 3.5-Gy fractions. Median time from diagnosis to reirradiation was...
متن کاملComparison with other low-grade brain tumors
Method: F o rty-two patients with low-grade brain tumor and re f r a c t o ry epilepsy were studied. The mean age was 22.3 years. They were divided into two groups: Group A, patients with ganglioglioma (n=19) and group B, patients with other low-grade tumors (n=23) (14 astrocytoma, 6 oligodend roglioma, 2 dysembryoplastic neuroepithelial tumor, and 1 xanthoastro c y t o m a ) . Results: Age at ...
متن کاملReirradiation of relapsed brain tumors in children.
AIM The aim of this study was to evaluate toxicity and response to fractionated reirradiation (FR) of relapsed primary brain tumors in children. BACKGROUND The treatment options for recurrent brain tumors in children previously irradiated are limited. Reirradiation is performed with fear due to the cumulative late CNS toxicity and the lack of a significant chance of cure. MATERIALS AND METH...
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ژورنال
عنوان ژورنال: Journal of Radiation Research and Applied Sciences
سال: 2021
ISSN: 1687-8507
DOI: 10.1080/16878507.2021.1935131